论文部分内容阅读
酸性成纤维细胞生长因子 是重要的蛋白药物 酸性成纤维细胞生长因子(acidic fibroblastgrowth factor,aFGF)是一种具有多方面功能的活性蛋白,它不但能够促进创伤修复,而且具有心肌保护、局部缺血保护、神经保护等作用。在FGF蛋白家族的23个成员当中,aFGF最早被人们发现,而且被认为是该家族的原型。但是,迄今为止国外的aFGF的药用研究还只是停留在实验室阶段。SDA在2001年正式批准暨南大学医药中心申报的外用创伤药物重组人aFGF进入临床试验阶段,同时,国家专利局批准了aFGF相关的两项
Acid fibroblast growth factor is an important protein drug. Acid fibroblast growth factor (aFGF) is a multifunctional active protein that not only promotes wound healing, but also has cardioprotection and ischaemia Protection, neuroprotection and other effects. Of the 23 members of the FGF protein family, aFGF was first discovered and is thought to be the prototype of this family. However, the medicinal research of aFGF abroad so far has only stayed in the laboratory. SDA formally approved in 2001 the Jinan University Medical Center declared topical trauma drug recombinant human aFGF entered the clinical trial phase, at the same time, the State Patent Office approved aFGF related to two