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目的探讨血清尿酸水平与中国人群肥胖的关系。方法入选960例无心血管病症状的普通社区人群,男751人,女209人,平均年龄41.27岁,所有研究对象进行了详细的问卷调查和体检。按照体重指数的四分位数,将研究对象分成4组,测量各组血清尿酸水平及高尿酸血症的发生情况。结果男性中,BMI从低到高的各组对象的血清尿酸水平分别为295.75±52.29umol/L,323.55±75.93umol/L,331.38±65.62umol/L,344.66±66.72umol/L,各组间差别都有显著性,随着BMI的升高,血清尿酸的水平呈线性增高。女性中,BMI从低到高的各组对象的血清尿酸水平分别为233.62±49.3umol/L,235.76±54.34umol/L,243.57±46.99umol/L,295.79±54.31umol/L,第4组显著高于其他3组。高尿酸血症的发生率逐步提高,分别为1.2%,3.8%,8.0%和13.5%,在校正了年龄、性别、吸烟状况、饮酒状况、血压、血脂、血糖等混杂因素后,BMI高的对象发生高尿酸血症的危险是BMI低的对象的5.38(1.50-19.37)倍,P=0.001。结论血清尿酸水平与肥胖显著相关。
Objective To investigate the relationship between serum uric acid level and obesity in Chinese population. METHODS: A total of 960 community-based general population without cardiovascular disease symptoms were enrolled, including 751 males and 209 females, with an average age of 41.27 years. All the subjects underwent detailed questionnaires and physical examinations. According to the quartile of body mass index, the subjects were divided into four groups, and the levels of serum uric acid and the incidence of hyperuricemia in each group were measured. Results In males, serum uric acid levels of the subjects with low to high BMI were 295.75 ± 52.29umol / L, 323.55 ± 75.93umol / L, 331.38 ± 65.62umol / L, 344.66 ± 66.72umol / L, The difference was significant. With the increase of BMI, serum uric acid level increased linearly. Serum uric acid levels were 233.62 ± 49.3umol / L, 235.76 ± 54.34umol / L, 243.57 ± 46.99umol / L, 295.79 ± 54.31umol / L in all the subjects with low to high BMI, Higher than the other three groups. The prevalence of hyperuricemia was gradually increased by 1.2%, 3.8%, 8.0% and 13.5%, respectively. After adjusting for age, sex, smoking status, drinking status, blood pressure, blood lipids, blood glucose and other confounders, The risk of developing hyperuricemia in subjects is 5.38 (1.50-19.37) fold, P = 0.001 for subjects with low BMI. Conclusion The level of serum uric acid is significantly correlated with obesity.