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钙通道阻滞剂的问世,是近数年来的心血管病药物治疗的重大进展。临床上最有效的钙通道阻滞剂有硝苯吡啶、异搏定和硫氮(艹卓)酮。它们在化学结构上完全不同,因而在电生理、药理学、血流动力学及临床效果上均有所不同。本文比较了这些不同作用,重点提出如何选用最合适的药物以治疗不同类型的心绞痛,以及这些药物联合应用时,应如何避免引起严重的副作用。
The advent of calcium channel blockers is a major advance in the treatment of cardiovascular diseases in recent years. Clinically the most effective calcium channel blockers are nifedipine, verapamil and sulfur nitrogen (艹 Zhuo) ketone. They are completely different in chemical structure and therefore differ in electrophysiology, pharmacology, hemodynamics and clinical effects. This article compares these different effects, highlighting how to choose the most appropriate drug to treat different types of angina and how to avoid serious side effects when these drugs are used in combination.