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在肿瘤的局部化疗中,要求药物能在肿瘤内和其周围长时间滞留,保持较高浓度,尽可能减少药物向全身扩散以降低副作用。本文用血管收缩剂硝酸萘唑啉(NPZ)加入治疗进展性和复发性乳房癌的阿霉素(ADR)软膏中,期望药物长时间在局部保持高浓度软膏处方为NPZ0.02g(0.05或0.5g)、ADR0.05g,聚乙二醇4000 25.00g、聚丙烯酰胺0.65g、羟丙基纤维素1.35g,加水至100g。将ADR软膏或NPZ-ADR软膏0.5g分别涂于去毛小鼠背部(3.1×4.1cm),1、
In the local chemotherapy of the tumor, it is required that the drug can stay in and around the tumor for a long time, maintain a high concentration, and minimize the spread of the drug to the whole body to reduce side effects. In this paper, vasoconstrictor nitazoxanide (NPZ) was added to adriamycin (ADR) ointment for the treatment of progressive and recurrent breast cancer. It is expected that the drug will be locally maintained at a high concentration ointment for a long time as NPZ0.02g (0.05 or 0.5 g), ADR 0.05g, polyethylene glycol 4000 25.00g, polyacrylamide 0.65g, hydroxypropylcellulose 1.35g, add water to 100g. 0.5 g of ADR ointment or NPZ-ADR ointment was applied to the back of the dehairing mice (3.1 x 4.1 cm), 1,