药物配伍禁忌是药物与机体相互作用本质的具体表现,历代医家经过不断的研究和长期的临床用药实践,总结出了以“十八反”为代表的中药配伍禁忌理论~([1])。但它们为什么反?怎么反?此类问题始终没有定论。从古至今,无论是历代方书、医案还是现在临床上均广为使用,而且现代毒理、药理研究也尚未给出一个确切的答案。然而,随着人们安全用药的意识不断 Contraindication of drug compatibility is the concrete manifestation of the essence of drug-body interaction. After years of continuous research and long-term clinical practice, physicians of all generations have summed up the taboo theory of traditional Chinese medicine represented by “anti-18” [1] ). But why do they react? How anti-? Such problems have not been conclusive. Since ancient times, both ancient prescriptions, medical records or are now widely used clinically, and modern toxicology, pharmacology research has not yet given an exact answer. However, with the constant awareness of safe drug use