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目的研究通补Ⅰ号对Ｄ－半乳糖衰老小鼠模型的大肠杆菌群的影响。方法采用２０±２ｇＩＣＲ品系小鼠用Ｄ－半乳糖造模，同时用通补Ⅰ号治疗，采用滴注法检测衰老模型小鼠大肠杆菌、双歧杆菌及拟杆菌数量。结果Ｄ－半乳糖衰老模型大肠杆菌群中大肠杆菌增多，拟杆菌、双歧杆菌变化不大，通补Ⅰ号具有防治此模型肠杆菌增多的作用。结论通补Ⅰ号可通过抑制肠杆菌的产生，达到延缓衰老之功效。
Objective To study the effect of Tongbu I on E. coli population in aging mouse model of D-galactose. Methods 20±2g ICR strain mice were used to make D-galactose, and Tongfu I was used for the treatment. The number of E. coli, Bifidobacterium and Bacteroides in aging model mice was detected by instillation method. Results There was an increase in E. coli in the Escherichia coli group of D-galactose aging model, Bacteroides and Bifidobacteria had little change, and Tongbu I had the effect of preventing and controlling the increase of Enterobacteriaceae in this model. Conclusion Tongbu I can achieve anti-aging effects by inhibiting the production of enterobacteriaceae.