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目的研究肝癌组织、癌旁组织中乙型肝炎表面抗原(HBsAg)、丙型肝炎抗原表达与血清肝纤维化标志物的相关性。方法采用免疫组织化学法对肝癌组织及癌旁组织中的HBsAg、丙型肝炎抗原表达进行了标记和分析,同时检测其血清肝纤维化标志物水平,并研究它们的相关性。结果肝癌血清肝纤维化标志物水平在乙型、丙型肝炎病毒混合感染组中最高,单独乙型、丙型肝炎病毒感染组次之,无病毒感染组最低,肝癌组织、癌旁组织中HBsAg、丙型肝炎抗原表达与透明质酸、层黏连蛋白、Ⅳ型胶原蛋白呈正相关,相关系数分别为0.60、0.45、0.46,P值均<0.01。结论肝癌遵循慢性病毒性肝炎、肝硬化、肝癌的发展趋势,有病毒感染的肝癌组织,其血清肝纤维化水平明显高于无病毒感染者。一方面病毒的感染是肝癌发生的原因,另一方面长期的病毒血症会加重肝脏组织病变,所以病毒性肝炎的抗病毒干预治疗对肝癌的预后有着积极的意义。
Objective To investigate the correlation between hepatitis B surface antigen (HBsAg), hepatitis C antigen (HCV) antigen expression and serum markers of liver fibrosis in hepatocellular carcinoma tissues and adjacent tissues. Methods Immunohistochemical method was used to mark and analyze the expression of HBsAg and hepatitis C antigen in liver cancer tissues and adjacent tissues. Meanwhile, the levels of serum markers of liver fibrosis were detected and their correlations were also studied. Results The level of serum liver fibrosis markers in HCC was the highest among the B and C hepatitis B virus mixed infection groups, followed by B and C hepatitis virus infection group, the lowest in the virus-free infection group, and the lowest in the HCC tissues and paracancerous tissues , The expression of hepatitis C antigen was positively correlated with hyaluronic acid, laminin and collagen Ⅳ, the correlation coefficients were 0.60,0.45,0.46, P <0.01 respectively. Conclusion Liver cancer follows the trend of chronic viral hepatitis, cirrhosis and hepatocellular carcinoma. The level of serum hepatic fibrosis in virus-infected HCC tissues is significantly higher than that in non-virus-infected patients. On the one hand, the virus infection is the cause of liver cancer, on the other hand, long-term viremia will aggravate liver tissue disease, so viral hepatitis antiviral intervention has a positive effect on the prognosis of liver cancer.