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猕猴静脉注射~(125)Ⅰ标记基因重组人白细胞介素-3(30μg/kg)后RHPLC测定血浆浓度曲线,快速和末端半衰期分别为(0.15± 0.13)和(2.21± 0.59)h.皮下注射30,90和180μg/kg消除半衰期2.0～3.8 h,AUC基本上随皮下注射(SC)剂量而增大,CL_s相近 吸收受注射部位浓度限制.生物利用度0.71.药物在体内迅速降解.组织分布泌尿系统浓度最高,胆肠道、淋巴、骨髓和脾等与血浆相近,脑最低尿分析提示肾是降解器官之一
The plasma concentration curve of RHCLC was (0.15 ± 0.13) and (2.21 ± 0.59) h after subcutaneous injection of ~ (125) Ⅰ labeled recombinant human interleukin-3 (30μg / kg) The half-lives of 30, 90 and 180 μg / kg were 2.0-3.8 h, AUC increased with the dosage of subcutaneous injection (SC), and the absorption of CL_s was limited by the injection site concentration. Bioavailability was 0.71. The drug rapidly degraded in vivo. Urinary system highest concentration, the gut, lymph, bone marrow and spleen and plasma similar to the lowest brain urinalysis prompted kidney is one of the degradation of organs