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目的:探讨磷酸肌酸钠(CP,里尔统)治疗心肌早期舒张功能障碍的疗效。方法:心肌舒张功能障碍患者138例,分为磷酸肌酸钠组(109例)常规治疗组(29例),所有患者均进行常规治疗。磷酸肌酸组在常规治疗的基础上,给予CP2g+5%葡萄糖或0.9%的氯化钠100ml静脉滴注,轻度舒张功能减低者每天1次,中度舒张功能减退者每天2次,连续7～14d为1疗程。采用彩色多普勒超声心动图检测二尖瓣口舒张早期峰值流速(E)、二尖瓣口舒张晚期峰值流速(A),二尖瓣环舒张早期速度峰值(Ea)、二尖瓣环舒张晚期速度峰值(Aa),计算E/A比值,Ea/Aa比值和E/Ea比值,对比治疗前后两组临床症状、体征及彩色多普勒超声心动图各指标改善情况。结果:治疗后两组患者所有症状和体征均有明显的改善(P<0.05～0.01),且磷酸肌酸钠组临床显效率(96.2%)明显高于常规治疗组的57.1%(P<0.01)。磷酸肌酸钠组E/A比值(81.65%∶10.34%)、Ea/Aa比值(83.49%∶13.79%)、E/Ea比值(92.86%∶12.00%)的显效率均显著高于常规治疗组的(P均<0.01)。结论:磷酸肌酸钠对于改善心脏舒张功能和病情有显著疗效。
Objective: To investigate the therapeutic effect of sodium creatine phosphate (CP) on early diastolic dysfunction in myocardium. Methods: 138 patients with myocardial diastolic dysfunction were divided into routine therapy group (n = 109) and sodium phosphate creatine group (n = 29). All patients were treated routinely. On the basis of routine therapy, creatine phosphate group was given intravenous drip of CP2g + 5% glucose or 0.9% sodium chloride 100ml once daily with mild diastolic dysfunction, twice daily with moderate diastolic dysfunction 7 ~ 14d for a course of treatment. Color Doppler echocardiography was used to measure the early diastolic mitral inflow velocity (E), mitral diastolic peak flow velocity (A), mitral annular early diastolic velocity peak (Ea), mitral annular dilatation (Aa), E / A ratio, Ea / Aa ratio and E / Ea ratio were calculated. The clinical symptoms, signs and color Doppler echocardiography were compared before and after treatment. Results: All the symptoms and signs of the two groups were significantly improved after treatment (P <0.05 ~ 0.01), and the clinical efficiency (96.2%) in the sodium creatinine group was significantly higher than that in the conventional treatment group (57.1%, P <0.01) ). E / A ratio (81.65%: 10.34%), Ea / Aa ratio (83.49%: 13.79%) and E / Ea ratio (92.86%: 12.00%) in sodium creatine group were significantly higher than those in the conventional treatment group (P <0.01). Conclusion: Creatine phosphate has a significant effect on improving diastolic function and disease.