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目的调查苏州吴江区人乳头状瘤病毒(human papillomavirus,HPV)感染现状及HPV分型的分布情况,分析其与TCT和病理活检结果的相关性。方法苏州吴江区检测中心参与初筛的患者进行23种HPV基因亚型检测,HPV检测结果高危阳性的受检者转诊进行液基细胞学检查,两者均异常者或单独HPV16、HPV18阳性再行阴道镜下活检。结果5 371例标本HPV总感染率为21.09%,≤25岁和46岁及以上HPV感染率较高,HPV单一性感染和多重性感染在各年龄阶段之间差异有统计学意义(P<0.01);多重HPV感染则以≤25岁和≥51岁高发;HPV16、HPV18阳性且TCT结果阳性的患者在不同宫颈病变中差异有统计学意义(P<0.05)。结论本地区最常见的高危HPV型别为16型、18型、33型和58型,而HPV不同亚型的单一和混合感染存在明显的年龄差异,导致宫颈病变的程度有所不同。
Objective To investigate the status of human papillomavirus (HPV) infection and the distribution of HPV typing in Wujiang District of Suzhou, and analyze its correlation with TCT and biopsy results. Methods Twenty-three kinds of HPV genotypes were detected in the patients who participated in the preliminary screening in Wujiang District, Suzhou. HPV test results showed high-risk subjects were referred for liquid-based cytology tests. Both were abnormal or HPV16 and HPV18 were positive. Colposcopy biopsy. Results The total infection rate of HPV in 5 371 specimens was 21.09%, the HPV infection rate was less than 25 years old and 46 years old and above, and the difference between HPV single infection and multiple infections was statistically significant (P<0.01). Multiplex HPV infections were higher than ≤25 years old and ≥51 years old; patients with positive HPV16, HPV18, and positive TCT results had statistically significant differences in different cervical lesions (P<0.05). Conclusions The most common high-risk HPV types in this region are type 16, 18, 33, and 58. There is a significant age difference between single and mixed infections of different HPV subtypes, resulting in different degrees of cervical lesions.