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目的:观察亚低温联合咪达唑仑治疗重症病毒性脑炎患者的疗效及对神经元特异性烯醇化酶(NSE)水平的影响。方法:将2010年6月至2015年6月株洲市中心医院收治76例重症病毒性脑炎患者,随机分为观察组和对照组,每组38例。对照组给予常规治疗,观察组在对照组基础上采用亚低温联合咪达唑仑治疗,观察两组的治疗效果及检测血清中NSE含量变化。结果:治疗后观察组总有效率明显高于对照组,随着治疗时间的增加两组患者血清NSE含量逐渐降低,治疗第5天和第10天,观察组患者血清NSE含量明显低于对照组,差异具有统计学意义(P<0.05)。结论:亚低温联合咪达唑仑治疗重症病毒性脑炎,治疗效果显著,总有效率高且能降低患者体内NSE含量。
Objective: To observe the effect of mild hypothermia combined with midazolam on patients with severe viral encephalitis and its effect on the level of neuron specific enolase (NSE). Methods: From June 2010 to June 2015, 76 patients with severe viral encephalitis were admitted to Zhuzhou Central Hospital. They were randomly divided into observation group and control group, with 38 cases in each group. The control group was given conventional treatment. The observation group was treated with mild hypothermia combined with midazolam on the basis of the control group. The therapeutic effect and the change of NSE level in the serum were observed. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group. With the increase of the treatment time, the serum NSE level gradually decreased in both groups. On the 5th and 10th days of treatment, the NSE level in the observation group was significantly lower than that in the control group , The difference was statistically significant (P <0.05). Conclusion: Mild hypothermia combined with midazolam in the treatment of severe viral encephalitis, the treatment effect is significant, the total effective and can reduce the NSE content in patients.