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人类白细胞抗原复合体(human leueoeyte antigen,HLA)是编码人类白细胞抗原的一群紧密连锁的基因群,是迄今己知基因中多态性最高的基因复合体,其编码的抗原在机体免疫应答和免疫调节中起着关键性作用。许多研究发现,HLA基因的多态性与疾病的遗传易感性有明显关系。自从1967年Amiel首次报道何杰金氏病与HLA-A2抗原关联以来,人们对HLA与疾病相关性的研究历史已经超过了
Human leukocyte antigen complex (HLA) is a group of closely linked gene cluster encoding human leukocyte antigen. It is the gene complex with the highest polymorphism so far known, and the encoded antigen is highly expressed in the immune response and immune Regulation plays a key role. Many studies have found that the genetic polymorphism of HLA is obviously related to the genetic predisposition of the disease. Since the first report of Amiel’s association with HLA-A2 antigen in 1967, there has been a history of more than a century of research on HLA-related diseases