心钠素是由心脏产生的一种循环性激素,具有强大的利钠、利尿、扩张血管和降低血压等多种作用。本文仅就心钠素对肾脏的作用做一概述。一、心钠素对肾脏的作用(一)作用于肾小球。实验研究表明,心钠素能选择地使肾小球入球动脉扩张,使出球动脉收缩,肾小球滤过率增多。另外,心钠素可直接改变肾小球的超滤过系数,而增加肾小球滤过率。(二)作用于近曲小管。心钠素对近曲小管无直接作用,但心钠素可以抑制血管紧张素Ⅱ所引起的藏体再吸收,而发挥其利钠利尿作用。(三)作用于 HenIe 氏襻和远曲小管。心钠素可间接地影响远曲小管钠的调节。这是由于抑制肾 Atrial natriuretic peptide (atrial natriuretic peptide) is a circulating hormone produced by the heart. It has powerful effects of sodium, diuresis, vasodilation and blood pressure reduction. This article only an overview of the role of atrial natriuretic peptide on the kidneys. First, the role of atrial natriuretic peptide on the kidneys (a) on the glomerular. Experimental studies have shown that atrial natriuretic factor can selectively make the glomerular access artery dilation, so that the ball of the artery contraction, glomerular filtration rate increased. In addition, atrial natriuretic peptide can directly change the glomerular ultrafiltration coefficient, and increase glomerular filtration rate. (B) role in the proximal convoluted tubule. Atrial natriuretic peptide has no direct effect on the proximal convoluted tubule, but atrial natriuretic peptide can inhibit the resorption of the body caused by angiotensin Ⅱ and exert its natriuretic effect. (C) role in HenI’s 襻 and distal convoluted tubules. Atrial natriuretic sodium can indirectly affect the distal tubule sodium regulation. This is due to the inhibition of the kidneys