【摘 要】
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INTRODUCTIONrnAlthough they both originate from the embryonic common cartilage anlagen, the growth plate (GP) and articular cartilage (AC) separate and develop unique structures and functions shortly after birth as the primary and secondary ossification c
【机 构】
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Department of Orthopaedic Surgery,School of Medicine,Washington University,St.Louis,MO,USA;Departmen
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INTRODUCTIONrnAlthough they both originate from the embryonic common cartilage anlagen, the growth plate (GP) and articular cartilage (AC) separate and develop unique structures and functions shortly after birth as the primary and secondary ossification centers form and expand.1 During early postnatal development, GP chondro-cytes are metabolically active and undergo a highly orchestrated sequence of events including cell proliferation followed by hypertrophic maturation, similar to the chondrocyte differentia-tion process that occurs during embryonic skeletogenesis.2 Normal functioning of GP chondrocytes determines longitudinal bone growth, and the cartilaginous extracellular matrix provides a template for future bone formation.3 Perturbation of the normal sequence of cartilage development and growth pre- and postnatally is known to cause a number of skeletal dysplasias in humans.
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