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目的：比较佛山药厂与默沙东药厂生产的复方依那普利片对原发性高血压（ＥＨ）的降压作用和不良反应。方法：按平行对照原则将轻、中度ＥＨ病人６２例（完成治疗６０例）分为２组。佛山生产组３０例，服复方依那普利片由１／２片（含依那普利２．５ｍｇ，氢氯噻嗪６．２５ｍｇ）开始，如未达显效标准，则每周成倍递增剂量１次，最大用量４片，每日早餐后顿服，用药４ｗｋ；默沙东生产组３０例服复方依那普利片的剂量、服法、疗程均与国产组相同。结果：２组总有效率均为１００％，不良反应少而轻，２种药的剂量为依那普利５～１０ｍｇ／ｄ，氢氯噻嗪１２．５～２５ｍｇ／ｄ，总有效率达７７％或８３％。结论：２个药厂生产的药物治疗ＥＨ均剂量小、疗效佳且安全。
OBJECTIVE: To compare the antihypertensive effects and adverse reactions of enalapril tablets in patients with essential hypertension (EH) produced by Foshan Pharmaceutical Factory and Merck Pharmaceuticals. Methods: According to the principle of parallel control, 62 cases of mild and moderate EH patients (60 cases completed treatment) were divided into two groups. Foshan production group of 30 cases, taking the compound enalapril tablets by 1/2 (enalapril 2.5mg, hydrochlorothiazide 6.25mg) start, if less than the markedly effective standard, the weekly dose doubling weekly increase , The maximum amount of 4 tablets, daily breakfast after Dayton clothing, medication 4wk; Merck East production group 30 cases of oral administration of enalapril tablets dose, service method, treatment and domestic groups are the same. Results: The total effective rate was 100% in both groups. The adverse reaction was less and less. The dosage of two drugs was enalapril 5 ~ 10mg / d, hydrochlorothiazide 12.5 ~ 25mg / d, the total effective rate was 77% or 83%. Conclusion: All the two pharmaceutical companies produced small doses of EH, with good efficacy and safety.