最近已阐明正己烷的体内代谢产物具有神经毒性作用。Kirch等的实验证明,10,000 ppm正己烷如混以1,000 ppm甲基乙基甲酮(MEK)时,则MEK能显著增强正己烷的末梢神经毒性。作者以前的实验证明:正己烷如混以甲苯,则甲苯能抑制正己烷的末梢神经毒性。本实验旨在阐明MEK对容许浓度水平的正己烷所致末梢神经毒性的影响。实验用雄性大鼠32只,随机分成四组(每组8只):100 ppm正己烷组、200 ppm MEK组、100 ppm正己烷加200ppmMEK组,及对照组(在同型染毒装置内饲养)。染毒组分别每日进行十二小时染毒。测定项目有体重、运动神经传导速度(MCV)、运动神经远端潜 It has recently been demonstrated that the n-hexane metabolites in vivo have neurotoxic effects. Experiments by Kirch et al. Demonstrated that MEK significantly enhance n-hexane peripheral neurotoxicity when 10,000 ppm n-hexane, such as 1,000 ppm methyl ethyl ketone (MEK), is mixed. The authors previous experiments show that: n-hexane mixed with toluene, the toluene can inhibit n-hexane peripheral neurotoxicity. The aim of this experiment was to elucidate the effect of MEK on the tolerable concentration of n-hexane induced peripheral neurotoxicity. Thirty-two male rats were randomly divided into four groups (n = 8): 100 ppm n-hexane group, 200 ppm MEK group, 100 ppm n-hexane plus 200 ppm MEK group and control group . The exposure groups were exposed to 12 hours daily. Measured items are weight, motor nerve conduction velocity (MCV), motor nerve distal submerged