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目的观察多塞平对支气管哮喘患者焦虑、抑郁情绪的治疗效果。方法选择2010年1月—2012年12月收治的支气管哮喘伴焦虑、抑郁情绪患者71例,随机分为对照组35例和观察组36例。对照组使用常规治疗方法。观察组在对照组的基础上使用多塞平,开始25 mg/次,2~3次/d,以后逐渐增加至总量100~250 mg/d,最大用量不超过300 mg/d。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗后,对照组焦虑和抑郁评分分别为(66.3±5.7)、(63.8±5.3)分,观察组分别为(45.5±2.8)、(43.1±4.0)分,两组比较差异均有统计学意义(t=19.600、18.610,均P<0.05)。治疗后,对照组肺功能方面FVC、FEV1/预计值、FEV1/FVC及MVV分别为(3.3±0.2)L、(55.8±8.5)%、(60.3±8.9)%、(48.6±4.1)%,观察组分别为(3.9±0.5)L、(73.2±12.2)%、(78.1±13.3)%、(57.5±6.5)%,两组比较差异均有统计学意义(t=6.603、6.954、6.608、6.878,均P<0.05)。对照组控制良好12例,基本控制14例,未控制9例,控制率74.3%;观察组控制良好23例,基本控制11例,未控制2例,控制率94.4%。两组控制率比较差异有统计学意义(χ2=5.508,P<0.05)。结论多塞平具有起效快、基本无不良反应等优点,能有效减少患者的焦虑和抑郁情绪,提高治疗效果,且临床治疗剂量小,作用时间长,药物价格低廉,值得临床推广应用。
Objective To observe the therapeutic effect of doxepin on anxiety and depression in patients with bronchial asthma. Methods From January 2010 to December 2012, 71 patients with bronchial asthma and anxiety and depression were randomly divided into control group (35 cases) and observation group (36 cases). Control group using conventional treatment. The observation group used doxepin on the basis of the control group, starting at 25 mg / time, 2 ~ 3 times / d, then gradually increasing to the total amount of 100 ~ 250 mg / d, the maximum dosage not exceeding 300 mg / d. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results After treatment, the scores of anxiety and depression in the control group were (66.3 ± 5.7) and (63.8 ± 5.3) points respectively, and the observation group were (45.5 ± 2.8) and (43.1 ± 4.0) points respectively. There were statistically significant differences between the two groups Significance (t = 19.600, 18.610, all P <0.05). After treatment, the values of FVC, FEV1 / FEV1 / FVC and MVV in the control group were (3.3 ± 0.2) L, (55.8 ± 8.5)%, (60.3 ± 8.9)% and (48.6 ± 4.1)%, (3.9 ± 0.5) L, (73.2 ± 12.2)%, (78.1 ± 13.3)% and (57.5 ± 6.5)% respectively in the observation group.The differences between the two groups were statistically significant (t = 6.603,6.954,6.608, 6.878, all P <0.05). In the control group, 12 cases were well controlled, 14 cases were basic control, 9 cases were uncontrolled and the control rate was 74.3%. The control group was controlled well in 23 cases, basic control in 11 cases and uncontrolled in 2 cases, the control rate was 94.4%. There was significant difference between the two control rates (χ2 = 5.508, P <0.05). Conclusion Docetaxel has the advantages of quick onset and almost no adverse reactions. It can effectively reduce the anxiety and depression of patients and improve the treatment effect. And it has a small clinical dose, long duration of action, low drug price and worthy of clinical application.