27例26～40岁,健康,月经规则的经产妇分为三组:9例放置惰性Nova-T,9例放置含铜Nova-T,另9例放置释放左旋18甲基炔诺酮(LNG)的Nova-T。3个月后观察宫颈粘液的变化。所有对象从周期第10天起到估计的排卵日每天取血样及宫颈粘液,在排卵日后一周,每天取血样,连续3天。用RIA测血中E_2、P和LH水平。用免疫浊度测定宫颈粘液中IgG、白蛋白和粘蛋白含量,用体外孵育法测定Cu-IUD对~(14)C-胆固醇自动氧化的影响。结果表明置环前、后三组妇女血中E_2水平无显著差异,黄体期P值表明所有妇女置环前均有排卵,置环后3个月LNG-IUD组8例中2例无排卵,其余6例排卵,但血中P值显著低于对照周期(P<0.001)和惰性IUD妇女(P< Twenty-seven women aged 26 to 40 with normal menstruation were divided into three groups: 9 patients with inert Nova-T, 9 patients with copper-containing Nova-T and the other 9 patients with the release of levonorgestrel 18 (LNG Nova-T. 3 months after the observation of cervical mucus changes. All subjects took blood samples and cervical mucus daily from the 10th day of the cycle to the estimated ovulation day. Blood samples were collected daily for 3 days after the ovulation day. Blood levels of E_2, P and LH were measured with RIA. The contents of IgG, albumin and mucin in cervical mucus were determined by immunoturbidimetric assay and the effect of Cu-IUD on the auto-oxidation of ~ (14) C-cholesterol was determined by in vitro incubation. The results showed that there was no significant difference in blood E2 levels between the three groups of women before and after setting the rings. P value of the luteal phase showed that all women had ovulation before ring setting. In the LNG-IUD group 3 cases, The other 6 ovulation, but the blood P value was significantly lower than the control period (P <0.001) and IUD women (P <