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目的:探讨MTX局部注射联合中西药对持续性异位妊娠的预防效果。方法:180例行输卵管保守性手术的患者随机分为A组(注射组90例)与B组(对照组90例),均行腹腔镜下输卵管切开取胚术。A组术中局部注射甲氨蝶呤预防PEP,术后口服米非司酮、中药宫外孕I号方,B组未使用。结果:A组术后3d、6d血清β-HCG均显著低于B组(P<0.01)。A组术后1例发生PEP,B组6例,有统计学意义。结论:腹腔镜下保守治疗输卵管妊娠,术后局部注射MTX、术后联合口服米非司酮、中药宫外孕I号PEP方能有效地减少PEP发生率。
Objective: To investigate the preventive effect of local injection of MTX and western medicine on persistent ectopic pregnancy. Methods: 180 cases of tubal conservative surgery were randomly divided into group A (90 cases in injection group) and group B (90 cases in control group). All patients underwent laparoscopic tubal surgery. Group A intraoperative injection of methotrexate PEP, postoperative oral mifepristone, Chinese medicine ectopic pregnancy I, B group did not use. Results: Serum β-HCG in group A at 3d and 6d after operation was significantly lower than that in group B (P <0.01). A group of postoperative PEP occurred in 1 case, B group 6 cases, with statistical significance. Conclusions: Laparoscopic conservative treatment of tubal pregnancy, postoperative local injection of MTX, combined with oral administration of mifepristone, Chinese medicine ectopic pregnancy IEPEP can effectively reduce the incidence of PEP.