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本工作用假孕大鼠探讨了几种抗早孕药物,即D-丙~6-去甘~(10)-LHRH-乙基胺、HCG、PGE+2和PGF_(2α)的衍生物ICI_(81008)降低血浆孕酮水平的机理。通过在体实验的方法,观察到这几种药物能减少卵巢组织中孕酮含量,提示它们通过此途径而降低血浆孕酮水平。离体实验的结果表明这几种药物对卵巢孕酮含量和分泌或无明显影响,或有刺激性的作用,似说明它们降低卵巢组织孕酮含量主要不是通过对卵巢的直接抑制作用。
In this study, several anti-early pregnancy drugs were explored in the pseudopregnant rats, that is, the derivatives of D-propane 6-degan 10HHHH-ethylamine, HCG, PGE 2 and PGF 2α, 81008) Mechanism of lowering plasma progesterone levels. Through in vivo experiments, we observed that these drugs reduced progesterone levels in ovarian tissue, suggesting that they may lower plasma progesterone levels through this pathway. In vitro results show that these drugs on the progesterone content and secretion of ovarian or no significant effect or stimulating effect, it seems that they reduce the progesterone content of ovarian tissue is not mainly through the direct inhibition of the ovary.