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目的:研究P33ING1b和P53蛋白在宫颈癌中表达的相关性。方法:应用免疫组织化学SP方法检测80例宫颈癌组织(A)、80例宫颈癌旁组织(B)及80例正常宫颈组织(C)P33ING1b和P53蛋白的表达。结果:P33ING1b和P53蛋白阳性结果分别在A组中有33例(41.25%)和36例(57.50%);B组中有11例(13.75%)和8例(10.00%);C组中有4例(5.00%)和3例(3.75%)。A组中共阳性表达25例(31.25%)。两者间有明显相关性(P<0.01)。结论:P33ING1b、P53蛋白在宫颈癌中的表达呈正相关关系。
Objective: To study the correlation between the expression of P33ING1b and P53 in cervical cancer. Methods: Immunohistochemical SP method was used to detect the expression of P33ING1b and P53 in 80 cases of cervical cancer (A), 80 cases of cervical cancer adjacent tissues (B) and 80 cases of normal cervical tissue (C). Results: The positive results of P33ING1b and P53 were 33 cases (41.25%) and 36 cases (57.50%) in group A, 11 cases (13.75%) and 8 cases (10.00%) in group B, 4 cases (5.00%) and 3 cases (3.75%). A group of positive expression in 25 cases (31.25%). There was a significant correlation between the two (P <0.01). Conclusion: There is a positive correlation between the expression of P33ING1b and P53 in cervical cancer.