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目的制备肺靶向阿霉素明胶微球(ADM-GMS)并考察其特性。方法采用天然可生物降解的明胶为载体材料,液体石蜡为油相,乳化化学交联法制备阿霉素明胶微球。结果微球形态圆整,平均粒径10.8μm,5-15μm的微球占总数的85.5%,载药量为4.05%,包封率为42.3%,体外释药具有缓释特征,(25±2)℃、RH=60%条件下放置6个月,其稳定性良好。结论微球的粒径、形态、堆密度、流动性、载药量和包封率、体外释药性能及稳定性等基本符合肺部靶向的要求。
Objective To prepare lung-targeted adriamycin gelatin microspheres (ADM-GMS) and investigate its characteristics. Methods Natural biodegradable gelatin as carrier material, liquid paraffin as oil phase and emulsified chemical cross-linking method were used to prepare adriamycin gelatin microspheres. Results The morphology of the microspheres was round. The microspheres with the average diameter of 10.8μm and 5-15μm accounted for 85.5% of the total number of microspheres. The drug loading was 4.05% and the entrapment efficiency was 42.3% 2) ℃, RH = 60% for 6 months, the stability is good. Conclusion The particle size, morphology, bulk density, fluidity, drug loading and entrapment efficiency, in vitro drug release properties and stability of microspheres are basically in line with the requirements of lung targeting.