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临床资料强烈提示幽门螺杆菌(Hp)是胃十二指肠疾病的重要病因,但确切的发病机制及最佳的抗菌治疗尚不清楚。用日本猴建立Hp动物模型,长期观察Hp感染后胃粘膜细胞增殖的系列变化。 材料与方法:13只野生日本猴,重7～11kg。接种Hp之前,实验动物口服羟氨苄青霉素干糖浆14天以杀灭胃内其他螺旋菌,口服碳酸氢钠和肌注法莫替丁3天以中和胃酸。禁食(不禁水)24小时后,其中6只猴麻醉后内镜下于胃窦喷洒Hp悬液5ml,另外7只猴作为对照
Clinical data strongly suggest that Helicobacter pylori (Hp) is an important cause of gastroduodenal disease, but the exact pathogenesis and the best antibacterial therapy is not clear. Hp animal model was established with Japanese monkey to observe the long-term changes of gastric mucosal cell proliferation after Hp infection. Materials and Methods: Thirteen wild Japanese monkeys weighing 7 ~ 11kg. Prior to Hp vaccination, experimental animals orally administered amoxicillin dry syrup for 14 days to kill other spirochaetes in the stomach, orally administered sodium bicarbonate and intramuscular famotidine for 3 days to neutralize gastric acid. Fasting (can not help but water) after 24 hours, of which 6 monkeys after anesthesia endoscopy in the antrum spray Hp suspension 5ml, another 7 monkeys as a control