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目的通过血清C-反应蛋白(CRP)和基质金属蛋白酶-9(MMP-9)的检测,探讨CRP、MMP-9在高血压颈动脉粥样硬化中的意义。方法采取双抗体夹心酶联免疫吸附试验,测定血清MMP-9的水平,采用免疫透射比浊法检测CRP,应用颈动脉超声检测颈动脉内膜状况,进行对比研究。结果高血压组血清MMP-9及CRP分别为(216±89)μg/L和(4.03±1.82)mg/L,明显高于对照组(P<0.01,P<0.05),高血压颈动脉内膜-中膜厚度(IMT)增高亚组,血清MMP-9血清CRP也高于TMT正常亚组(P<0.01,P<0.05),且颈动脉IMT与MPP-9、CRP正相关。结论 MMP-9、CRP与高血压颈动脉粥样硬化程度相关,可作为评价高血压颈动脉粥样硬化的良好指标。
Objective To investigate the significance of CRP and MMP-9 in the hypertensive carotid atherosclerosis by detecting serum C-reactive protein (CRP) and matrix metalloproteinase-9 (MMP-9). Methods Serum MMP-9 levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA), CRP was detected by immunoturbidimetric assay, and the carotid artery intima was examined by carotid ultrasonography. Results The serum levels of MMP-9 and CRP in hypertension group were (216 ± 89) μg / L and (4.03 ± 1.82) mg / L respectively, significantly higher than those in control group (P <0.01, Serum MMP-9 serum CRP was also significantly higher in patients with elevated IMT (P <0.01, P <0.05), and IMT was positively correlated with MPP-9 and CRP in carotid arteries. Conclusion MMP-9 and CRP are correlated with the degree of carotid atherosclerosis in hypertension and can be used as a good indicator to evaluate carotid atherosclerosis in hypertension.