作者在两组全身性严重疾患伴循环不足的外科病人中观察PGE_1对血流动力学和氧输送的作用。组Ⅰ12例为公开给药组,组Ⅱ20例为随机的安慰剂对照组,其中10例接受PGE_1,余10例接受安慰剂。PGE_1在输液治疗使肺动脉楔压达15～20 mm Hg(平均18±2)时给予,此时循环和代谢功能并未获得满意的纠正。两组结果均示PGE_1改善了心输出量、心搏量、氧输送和氧耗量,降低了肺血管阻力和肺动脉压。组Ⅰ中除3例(1例于术后给予PGE_16天,另2例年龄分别为95岁和73岁)改善较少外,其它病例均得到显著的改善。组Ⅱ中安慰剂对照组有2例死亡,而PGE_1组却 The authors observed the effects of PGE 1 on hemodynamics and oxygen delivery in two surgical patients with systemic severe disease with under-circulation. Groups I12 were openly dosed and group II20 were randomized placebo controls, 10 of whom received PGE1 and the remaining 10 received placebo. PGE_1 was given when infusion of pulmonary artery wedge pressure reached 15-20 mm Hg (mean 18 ± 2), at which time the circulatory and metabolic functions were not satisfactorily corrected. Both groups showed that PGE_1 improved cardiac output, stroke volume, oxygen delivery and oxygen consumption, decreased pulmonary vascular resistance and pulmonary arterial pressure. Group I except for 3 cases (1 case of postoperative PGE_16 days, the other two cases were 95 years old and 73 years old) less improvement in other cases were significantly improved. Two of the placebo-controlled groups in Group II died, whereas the PGE_1 group did