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茶碱对慢性阻塞性肺部疾病(CoPD)患者的睡眠时呼吸紊乱和睡眠质量有无影响尚未明了。这类病人常常诉说妨碍睡眠,呼吸困难和夜晚咳嗽,为此我们用双盲、随机、交叉对照试验,研究用β-受体兴奋剂治疗COPD时合并应用茶碱的临床疗效,及其对睡眠和夜间呼吸功能的影响。受试者为12例男性COPD患者,平均年龄62.8±2.5岁。1秒钟用力呼气量(FEV_1)为1.36±0.11升。
Whether or not theophylline has effects on sleep disturbance and sleep quality in patients with chronic obstructive pulmonary disease (CoPD) has not been elucidated. For this reason, we used double-blind, randomized, cross-over controlled trials to investigate the clinical efficacy of theophylline in combination with β-receptor agonists in the treatment of COPD, and their effect on sleep And the effects of breathing at night. The subjects were 12 male COPD patients with an average age of 62.8 ± 2.5 years. One second forced expiratory volume (FEV_1) was 1.36 ± 0.11 liters.