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为建立人脑膜瘤的动物模型，我们从临床中获得的５ 例脑膜瘤手术标本移植于裸鼠肾包膜下和皮下，结果肾包膜下移植的１２ 只裸鼠有１１ 只获得肿瘤生长，成功率９１－７ ％ 。肿瘤的体积在４ ～１０ 周可达原体积的２ ～３ 倍。血管形成很明显，并随肿瘤体积不断增大而数目增多，管径增粗。病理切片示移植于裸鼠的肿瘤与原外科手术切除的标本在形态学上一致，保持了人类脑膜瘤的形态特点。而皮下移植的６ 只裸鼠仅１ 只出现肿瘤成活，成功率为１６－７ ％ 。二组之间经统计学处理有显著性差异（ Ｐ＜ ０－０１） 。这项研究表明人类脑膜瘤在裸鼠肾包膜下移植是一种很好的模型建立方法，并为研究人类脑膜瘤的激素调控以及综合治疗提供了基础
To establish a human meningioma animal model, we obtained from the clinical 5 cases of meningioma surgical specimens were transplanted into the subcutaneous and subcutaneous nephric in nude mice, the results of renal capsule transplanted in 12 of 12 nude mice to obtain tumor growth, The success rate of 91-7%. Tumor volume up to 4 ~ 10 weeks in the original volume of 2 to 3 times. Vascular formation is obvious, and with the increasing volume of the tumor increased in number, diameter thickening. Pathological sections showed that the tumors transplanted in nude mice were morphologically identical with those of the original surgical resection and maintained the morphological characteristics of human meningioma. However, only one of the 6 nude mice transplanted subcutaneously survived with a success rate of 16-7%. There was a significant difference between the two groups by statistical analysis (P <0-01). This study shows that transplantation of human meningioma in the subcutaneous capsule of the kidney in nude mice is a good method for establishing a model and provides a basis for the study of hormonal regulation and comprehensive treatment of human meningiomas