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作者对28名由病史、临床症状体征、乙状结肠镜检查及其它检查包括服用粗麦麸食物4周等诊断为过敏性结肠综合征(IBS)的患者(男7例,女21例,平均35岁),应用洛哌丁胺或安慰剂进行双盲交叉试验。剂量开始二周为2mg(一片),每日2次,随后依个体需要可调整剂量至每次4 mg,每日3次。随机持续服药五周,并观察大便次数、性状及腹胀、腹痛、便意等情况。同时给病人进食混有放射性~(99m)锝25微居里的试验餐,把闪烁计数器放在腹部最大计数部位,每10分钟按胃内放射性测定胃排空时间一次,通过测定进食食物到呼吸氢浓度持续升高时间来确定小肠输送时间,从进食到餐后大便排出50％
The authors evaluated 28 patients (7 males and 21 females, average 35 years) diagnosed as having allergic colon syndrome (IBS) by medical history, clinical signs and symptoms, sigmoidoscopy and other tests, ), Double-blind crossover with loperamide or placebo. The first two weeks of the dose of 2mg (a), 2 times a day, followed by individual needs can be adjusted to a dose of 4mg, 3 times a day. Random five-week continuous medication, and observe stool frequency, traits and abdominal distension, abdominal pain, meaning and so on. At the same time, the patient was given a test meal mixed with 25 μg of radioactive 99 technetium technetium, placing the scintillation counter at the maximum counting position of the abdomen, measuring gastric emptying time by radioactivity every 10 minutes, measuring food intake to the respiration Hydrogen concentration continued to rise time to determine intestinal transit time, from eating to postprandial stool discharge 50%