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近有报道,甘草根的乙醇抽提物在体外试验中能抑制大型热带利什曼原虫及杜氏利什曼原虫前鞭毛体。生物分析表明,甘草查耳酮A(licochalcone A)为主要活性成份。本文作者在体外和体内试验中测定了该化合物的抗疟活性。 体外试验为以Trager和Jensen法培养恶性疟原虫敏感株(3D7)及氯喹抗性株
It has been reported recently that ethanol extract of licorice root can inhibit large-sized Leishmania tropicalis and Leishmania donovani pre-flagella in vitro tests. Bioanalysis showed that licochalcone A was the main active ingredient. The authors determined the anti-malarial activity of this compound in vitro and in vivo. In vitro experiments to Trager and Jensen method of Plasmodium falciparum-sensitive strains (3D7) and chloroquine resistant strains