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目的:观察氨氯地平与阿托伐他汀联合治疗单纯收缩期高血压老年患者的疗效及安全性,探索其临床价值。方法:回顾性分析90例老年单纯收缩期高血压患者的临床资料,随机分为两组,观察组(n=52)应用氨氯地平+阿托伐他汀口服治疗,对照组(n=38)氨氯地平口服;根据血压变化,治疗2周内血压仍不降低者增大剂量;治疗并观察6个月,对比降压情况及不良反应发生情况。结果:治疗后收缩压均达标,两组无显著性差异(P>0.05)。两组的脉压、舒张压均有显著性差异(P<0.05);对照组不良反应发生率为21.1%(8/38);观察组发生率为5.77%(3/52),两组差异有显著性。结论:氨氯地平与阿托伐他汀联合治疗老年单纯收缩期高血压安全有效,不仅能有效降低收缩压,而且还能显著降低脉压差,不良反应少,具有临床推广价值。
Objective: To observe the efficacy and safety of amlodipine combined with atorvastatin in senile patients with isolated systolic hypertension and to explore its clinical value. Methods: The clinical data of 90 elderly patients with isolated systolic hypertension were retrospectively analyzed. Patients in the observation group (n = 52) were treated with amlodipine and atorvastatin orally, while those in the control group (n = 38) Amlodipine oral; according to changes in blood pressure, blood pressure within 2 weeks of treatment is not reduced to increase the dose; treatment and observation of 6 months, compared to antihypertensive and adverse reactions. Results: After treatment, systolic blood pressure reached the standard, no significant difference between the two groups (P> 0.05). The pulse pressure and diastolic blood pressure were significantly different between the two groups (P <0.05). The incidence of adverse reactions in the control group was 21.1% (8/38) and in the observation group (5.77%, 3/52) Significant. Conclusion: The combination of amlodipine and atorvastatin is safe and effective in elderly patients with isolated systolic hypertension, which not only can effectively reduce the systolic blood pressure, but also can significantly reduce the pulse pressure difference and less adverse reactions, and has clinical value of popularization.