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目的检测老年慢性支气管哮喘患者血清中白细胞介素(IL)-12、-18和-35的水平,探讨其临床意义。方法确诊为支气管哮喘的老年患者62例作为观察组,21例健康成人血清标本作为对照组,检测两组血清中IL-12、IL-18和IL-35的表达水平。结果两组血清中IL-12、IL-18和IL-35的表达差异显著,观察组中IL-12、IL-18和IL-35的表达与病变的不同阶段相关,观察组中IL-12和IL-18具有正相关性,而其他指标间未见明显相关性。结论老年慢性支气管哮喘患者血清中IL-12、IL-18高表达、IL-35低表达与病变的形成和发展阶段有关。
Objective To detect the levels of interleukin (IL) -12, -18 and -35 in elderly patients with chronic bronchial asthma and to investigate its clinical significance. Methods Twenty-two elderly patients with bronchial asthma were selected as the observation group and 21 healthy adult serum samples as the control group. The serum levels of IL-12, IL-18 and IL-35 in the two groups were detected. Results The serum levels of IL-12, IL-18 and IL-35 in the two groups were significantly different. The expression of IL-12, IL-18 and IL-35 in the observation group was correlated with the different stages of the disease. And IL-18 has a positive correlation, while no significant correlation between other indicators. Conclusions Serum levels of IL-12 and IL-18 in elderly patients with chronic bronchial asthma are high, and the low expression of IL-35 is associated with the development and progression of the disease.