恶性脑胶质瘤是神经外科最常见的肿瘤，经所谓“标准治疗”（即手术＋放疗＋全身化疗）后，仍难以达到根治，其中位生存期不足1年[1]。临床及景像学均证实，几乎所有的恶性胶质瘤术后均要复发，90％以上的复发位于原发灶的2cm以内[2，3]。虽然目前立体定向放射外科间质内放疗及 Malignant gliomas are the most common tumors in neurosurgery. After the so-called “standard treatment” (ie surgery + radiotherapy + systemic chemotherapy), malignant gliomas are still difficult to achieve. The median survival time is less than 1 year [1]. Clinical and imaging studies have confirmed that almost all of the glioblastoma recurrence after surgery, more than 90% of the recurrence in the primary tumor within 2cm [2,3]. Although the current stereotactic radiosurgery and interstitial radiotherapy