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我们经过近十年的努力,在关键技术上,利用癌基因激活的原理和亚硝胺器官亲和性的特点,创造性地把体内外诱癌的方法结合起来,创造性地设计了新的诱癌方法,用亚硝胺成功地诱发了人胎儿食管上皮癌。为化学致癌的研究提供了新的途径,为证实亚硝胺是人类肿瘤病因因素提供直接证据。一、NMBzA诱发人食管上皮癌的研究我们在培养人胎儿食管上皮的培养液中加入林县环境中发现的甲基苄基亚硝胺(NMBzA)3个月后,发现食管上皮不同程度的增生性变化。将与NMBzA和未与
After nearly a decade of hard work, we used the principle of oncogene activation and the characteristics of nitrosamines’ organ affinity in key technologies to creatively combine in vitro and in vivo methods of cancer induction to creatively design new cancer-inducing methods. Methods, human fetal esophageal epithelial cancer was successfully induced with nitrosamines. It provides a new approach for the study of chemical carcinogenesis and provides direct evidence that nitrosamines are the cause of human tumors. I. NMBzA-induced human esophageal epithelial cancer research We have added the methylbenzyl nitrosamines (NMBzA) found in Linxian environment to culture fluids of human fetal esophageal epithelium for 3 months and found that the esophageal epithelium has different degrees of proliferation. Changes in sex. Will be with NMBzA and not with