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【目的】 探讨脐血瘦素水平与胎儿宫内生长发育相关性。 【方法】 采用放免检测新生儿脐血瘦素水平 ,采用Ponderal指数〔PI=10 0×体重 (g) /身长 (cm) 3 〕估测新生儿营养状态 ,采用weststrate公式〔F % =0 .8848×SFT4+0 .0 2 2〕估测新生儿体脂含量。 【结果】 3 7例适于胎龄儿 (AGA)脐血瘦素水平为 ( 10 .5 7± 3 .0 3 ) μg/L ,不同性别AGA脐血瘦素水平无显著差异 (P >0 .0 5 )。 13例大于胎龄儿 (LGA)脐血瘦素水平为 ( 13 .15± 3 .5 1) μg/L ,显著高于AGA(P =0 .0 14 ) ;15例小于胎龄儿 (SGA)脐血瘦素水平为 ( 8.0 5± 2 .69) μg/L ,显著低于AGA(P =0 .0 0 72 )。脐血瘦素水平与新生儿出生体重 (BW )相关系数r=0 .65 (P <0 .0 1) ,与新生儿体脂含量 (F % )相关系数r =0 .2 8(P <0 .0 5 ) ,与新生儿Ponderal指数 (PI)相关系数r =0 .62 (P <0 .0 1)。 【结论】 脐血瘦素水平是胎儿宫内生长发育状态的敏感指标 ,脐血瘦素可能是胎儿宫内生长发育的调节因子。
【Objective】 To investigate the correlation between cord blood leptin level and intrauterine growth and development. 【Method】 Cord blood leptin level was detected by radioimmunoassay. Ponderal index (PI = 10 0 × g / cm 3) was used to estimate the nutritional status of newborns. Weststrate formula [F% = 0] was used. 8848 × SFT4 +0 .0 2 2] estimated body fat content in newborns. 【Results】 The level of cord blood leptin in 37 maternal age-matched (AGA) patients was (10. 57 ± 3. 0 3) μg / L. There was no significant difference in cord blood leptin levels between different sexes (P> .0 5). The cord blood leptin level in 13 cases of LGA was (13.15 ± 3.51) μg / L, significantly higher than that of AGA (P = 0.144); 15 cases of SGA ) Cord blood leptin level was (8.05 ± 2.69) μg / L, significantly lower than that of AGA (P = 0.0072). The correlation coefficient between cord blood leptin level and newborn birth weight (BW) was 0.65 (P <0.01), and neonatal body fat content (F%) was 0.82 (P < 0 .0 5), and the Ponderal index (PI) correlation coefficient r = 0.62 (P <0.01). 【Conclusion】 Cord blood leptin level is a sensitive indicator of intrauterine growth and development status. Cord blood leptin may be a regulator of intrauterine growth and development.