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最近在检查非小细胞肺癌(NSCLC)石蜡包埋组织标本中的上皮生长因子受体(EGFR)的表达时,用抗 EGFR 单克隆抗体29.1对标本进行免疫组化染色,发现 EGFR 的表达与手术切除后的良好预后相关.由于此种抗体与血型 A 抗原的肽链呈交叉反应,故探讨肿瘤细胞血型抗原的表达对肺癌患者的预后是否亦有同样重要性。方法 253例手术治疗的肺癌患者,从符合标准的175例肿瘤标本中选择164例进行免疫组化染色。以
Recently, when examining the expression of epidermal growth factor receptor (EGFR) in paraffin-embedded tissue samples of non-small cell lung cancer (NSCLC), immunohistochemical staining of the specimens with the anti-EGFR monoclonal antibody 29.1 revealed that EGFR expression and surgery The good prognosis after resection is related. Since this antibody cross-reacts with the peptide chain of blood group A antigen, it is equally important to investigate whether the expression of blood group antigen of tumor cells is related to the prognosis of lung cancer patients. Methods A total of 253 surgically treated lung cancer patients were selected from 175 tumor specimens meeting the criteria for immunohistochemical staining. To