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前列腺素是一类20碳不饱和脂肪酸的衍生物,含一个环戊烷环及两条侧链。身体绝大多数细胞都能合成前列腺素(PGs),PGs在细胞内发挥第二信使作用,及/或发挥细胞内调节剂的作用。PGs被合成后便释放入细胞周围环境,对周围细胞产生局部作用,由于PGs可被肺、肾及肝降解,迅速从血循环中消失,故属于“局部性”激素。PGs除参与许多生理活动调节外,还与一些病理过程的发生发展有关,本文就PGs在休克过程中的作用进行综述。
Prostaglandins are a class of derivatives of 20-carbon unsaturated fatty acids that contain a cyclopentane ring and two side chains. The vast majority of cells in the body synthesize prostaglandins (PGs), which act as second messengers in the cell and / or act as intracellular regulators. After being synthesized, PGs are released into the surrounding environment and exert a local effect on the surrounding cells. As PGs can be degraded by the lungs, kidneys and liver and rapidly disappear from the blood circulation, PGs are “localized” hormones. In addition to being involved in many physiological activities, PGs are also involved in the development of some pathological processes. This review summarizes the role of PGs in shock progression.