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目的:探讨肝病患者血清铁蛋白检测的临床诊断意义及在肝损伤过程中的作用。方法:选择2010年1月—2013年12月诊治的376例肝病患者(慢性肝炎147例,肝硬化133例,肝细胞癌96例)和90例健康体检者作为研究对象,采用化学发光法对各组血清铁蛋白检测并比较。结果:与健康者相比,肝病患者血清铁蛋白水平明显升高,差异有统计学意义(P<0.05);与慢性肝炎、肝硬化患者相比,肝细胞癌患者血清铁蛋白水平明显升高,差异有统计学意义(P<0.05)。肝病患者血清铁蛋白水平与谷丙转氨酶(ALT)、谷草转氨酶(AST)呈正相关。结论:血清铁蛋白为肝病诊断提供参考依据,指导肝病的临床诊断和预后。
Objective: To investigate the clinical significance of serum ferritin in liver disease and its role in liver injury. Methods: 376 cases of liver disease (147 cases of chronic hepatitis, 133 cases of hepatocirrhosis, 96 cases of hepatocellular carcinoma) and 90 cases of healthy volunteers who were diagnosed and treated from January 2010 to December 2013 were selected as research objects. The chemiluminescence Each group of serum ferritin detection and comparison. Results: Serum ferritin levels in patients with liver disease were significantly higher than those in healthy controls (P <0.05). Compared with patients with chronic hepatitis and cirrhosis, serum ferritin levels in patients with hepatocellular carcinoma were significantly increased , The difference was statistically significant (P <0.05). Serum ferritin levels in patients with liver disease were positively correlated with alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Conclusion: Serum ferritin provides a reference for the diagnosis of liver disease, and guides the clinical diagnosis and prognosis of liver disease.