垂体肿瘤时因ACTH、皮质醇分泌过多,导致柯兴氏综合征,可进行手术治疗。术前辅助治疗药(美替拉酮、氨基格鲁米特等)能抑制皮质醇的合成、分泌,以改善病人的临床症状及代谢状态。当切除术不成功或有手术禁忌症时,也可考虑药物疗法。然而由于药物的副作用大、耐受性差,使其应用受到限制。近来发现酮康唑可用于柯兴氏综合征。 Pituitary tumors due to ACTH, cortisol excessive secretion, leading to Cushing’s syndrome, for surgical treatment. Preoperative adjuvant therapy drugs (metyrapone, aminoglutamate, etc.) can inhibit the synthesis and secretion of cortisol to improve the patient’s clinical symptoms and metabolic status. Drug therapy may also be considered when the procedure is unsuccessful or contraindicated. However, due to the side effects of drugs, poor tolerance, its application is limited. Ketoconazole has recently been found to be useful in Cushing’s syndrome.