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肿瘤细胞的多药耐受现象由磷酸糖蛋白 ( P- gp)过度表达所致 ,P- gp功能显像能在体内无创伤地评价 P- gp的表达。目前 ,用于 P- gp功能显像的 99m Tc标记亲脂性阳离子显像剂主要有MIBI、tetrofosmin、Q类化合物等。
The multidrug resistance phenomenon of tumor cells is caused by overexpression of phosphoglycoprotein (PGP). P-gp function imaging can in vivo evaluate the expression of P-gp in a non-invasive manner. Currently, 99m Tc-labeled lipophilic cationic imaging agents for P-gp function imaging mainly include MIBI, tetrofosmin, and Q compounds.