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在心脏直视手术中应用钙阻断剂是近年所研究的心肌保护方法之一。动物实验和临床观察表明,钙阻断剂对加强钾停跳液的保护效果,减轻“复灌期损伤”(即“再灌注损伤”)有所裨益。本实验应用新型钙阻断剂硝苯苄胺啶(YC-93),采用在体循环灌流离体兔心模
The use of calcium blockers in open heart surgery is one of the methods of myocardial protection that has been studied in recent years. Animal experiments and clinical observations indicate that calcium blockers have a beneficial effect on enhancing the protective effect of potassium cardioplegia and alleviating the “reperfusion injury” (ie, “reperfusion injury”). In this study, a new calcium blocker nifedipine (YC-93), using in vitro perfusion in vitro rabbit heart model