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目的 调查广州市区40岁以上人群夏季体内维生素D (VitD) 的水平.方法 随机选取2018年5月至10月广东药科大学附属第一医院门诊及住院590例年龄≥40岁人群, 所有研究对象均清晨空腹取静脉血, 采用Cobase 6000型电化学发光仪 (瑞士, 罗氏诊断) 检测血清25-羟维生素D[25 (OH) D]水平, 日立-7180型自动生化分析仪测定血钙 (Ca) 水平.结果590例年龄≥40岁人群中男性患者238例, 25 (OH) D平均水平为 (57.09±24.06) nmol/L, 女性患者352例, 25 (OH) D平均水平 (53.71±22.63) nmol/L.其中男性VitD正常占24.79％, 不足占34.45％, 缺乏占33.19％, 严重缺乏占7.56％;女性VitD正常占15.63％, 不足占37.22％, 缺乏占40.63％, 严重缺乏占6.53％.广州市区40岁以上人群夏季以VitD缺乏和不足较常见, 且男女两组总体25 (OH) D水平差异无统计学意义, 仅在80岁以上人群中, 男性25 (OH) D水平显著高于女性 (P=0.026、0.043).结论 本研究显示广州市区40岁以上人群夏季中25 (OH) D不足和缺乏现象较普遍, 且无性别差异, 而在80岁以上人群中, 女性25 (OH) D水平显著低于男性.维生素D的摄人有必要应引起重视.“,”Objective We aimed to describe the vitamin D status of Guangzhou subjects aged≥40 years in summer.Method In the present study, serum 25-hydroxyvitamin D and serum calcium were examined of 590 subjects aged≥40 years from May to Oct. Results we had to exclude 238 males with average level of 25 (OH) D was (57.09±24.06) nmol/L, and 352 females with average level of 25 (OH) D was (53.71±22.63) nmol/L. Among our subjects, the normal vitamin D status accounted was 24.79％, vitamin D deficiency was 33.19％, insufficiency was 34.45％, serious VitD deficiency was 7.56％ in group Male. The normal vitamin D status accounted was 15.63％, vitamin D deficiency was 40.63％, insufficiency was 37.22％, serious vitamin D deficiency was 6.53％ in group Female. vitamin D inadequacy existed generally in subjects aged ≥ 40 years. There was statistic difference between males and females subjects aged ≥ 80 years (P=0.026, P=0.043). Conclusion Vitamin D deficiency and insufficiency is very common in subjects aged ≥ 40 years living in Guangzhou in summer. In subjects aged ≥ 80 years, Male group was significantly higher than Female group. Vitamin D intakes should be taken into account.