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肿瘤细胞获得耐药表型是导致化疗失败的重要原因,为了弄清乳腺癌细胞多西紫杉醇耐药的调节机制及寻找治疗的分子靶点,研究者针对在多西紫杉醇耐药的乳腺癌患者高表达的36个基因设计各自的si RNA,并检测它们促进多西紫杉醇耐药细胞系MCF7-ADR凋亡的作用。结果表明下调作为N-寡糖
In order to find out the regulatory mechanism of docetaxel resistance in breast cancer cells and to find the molecular targets for the treatment, the researchers aimed at investigating the effects of docetaxel-resistant breast cancer patients The 36 highly expressed genes were designed for their respective si RNAs and tested for their role in promoting apoptosis in the docetaxel-resistant cell line MCF7-ADR. The results show down-regulation as N-oligosaccharides