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目的:研究人体小脑神经元的发育过程。方法:应用体视学方法,对18例不同时期人体小脑组织Golgi染色后进行观察,观测小脑皮质分层出现的时间,观测并计算神经元的数密度、体密度和表面积密度。结果:6月龄时,小脑皮质出现较明显的分子层、蒲肯野细胞层和颗粒层;星形细胞、篮状细胞、蒲肯野细胞、颗粒细胞和高尔基细胞的的数密度随月龄/年龄的增长而减少,体密度和表面积密度随月龄/年龄的增长而增加,但这些减小和增大是不等速的,6-8月龄变化最明显。结论:人体小脑神经元的发育呈现快慢交替、不均速发展,6～8月是小脑神经元发育的重要时期。
Objective: To study the development of human cerebellar neurons. Methods: Stereological methods were used to observe Golgi staining of cerebellum in 18 different periods of human cerebellum. The appearance time of cerebellar cortex was observed. The number density, body density and surface area density of neurons were observed and calculated. Results: At 6 months of age, the cerebellar cortex appeared more obvious molecular layer, Purkinje cell layer and granular layer. The number density of astrocytes, basal cells, Purkinje cells, granulosa cells and Golgi cells increased with age / Age, the body density and surface area density increase with age / age, but these decreases and increases are not constant, and the changes are the most obvious in 6-8 months. Conclusion: The development of human cerebellar neurons alternates rapidly and slowly, and develops unevenly. From June to August, it is an important period for the development of cerebellar neurons.