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目的:检测转化生长因子α(TGF-α)在胰腺疾病患者血清中的水平及其意义.方法:采用放射免疫法检测了35名正常人,31例急性胰腺炎,24例慢性胰腺炎及43例胰腺癌患者血清中TGF-α的含量.结果:正常血清TGF-α水平为(5.9±1.6)ng·L-1,急性胰腺炎为(5.7±2.1)ng·L-1;慢性胰腺炎为(6.1±1.9)ng·L-1;胰腺癌为(13.5±7.7)ng·L-1.与正常组及其他组相比,胰腺癌血清中TGF-α水平明显升高(P<0.01).结论:TGF-α在胰腺癌患者血清中明显升高,对胰腺癌的发生发展可能起了重要作用,对胰腺癌的诊断有一定的意义.
Objective: To detect the level of transforming growth factor-α (TGF-α) in the serum of patients with pancreatic diseases and its significance.Methods: 35 normal subjects, 31 acute pancreatitis, 24 chronic pancreatitis and 43 chronic pancreatitis were detected by radioimmunoassay The levels of TGF-α in the serum of patients with pancreatic cancer were determined by immunohistochemistry.Results The level of TGF-α in normal serum was (5.9 ± 1.6) ng · L -1 and that of acute pancreatitis was (5.7 ± 2.1) ng · L -1, (6.1 ± 1.9) ng · L-1 and (13.5 ± 7.7) ng · L-1 respectively.Compared with normal group and other groups, the level of TGF-α in pancreatic cancer was significantly increased (P <0.01) ) Conclusion: TGF-α is significantly elevated in the serum of patients with pancreatic cancer and may play an important role in the development of pancreatic cancer, which is of certain significance for the diagnosis of pancreatic cancer.