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本文总结了巯甲丙脯酸治疗充血性心衰60例的临床经验。急性左心衰8例,服药25mg后6h,症状均获缓解。单用本药的慢性心衰23例,治疗有效率70％;与强心甙及/或利尿剂合用者29例,有效率为79％。全组治疗后的心功能由治疗前的3.3级改善为2.3级。血流动力学资料表明,治疗后的平均动脉压、右房压、肺动脉压、外周及肺血管阻力显著下降;心排量及心作功指数增加。绝大多数患者均能很好耐受。就其作用特点及机理进行了讨论。
This article summarizes the clinical experience of captopril in the treatment of 60 cases of congestive heart failure. Acute left heart failure in 8 cases, taking 6mg after 6mg, the symptoms were relieved. 23 cases of chronic heart failure alone with the drug, the treatment efficiency of 70%; and cardiac glycosides and / or 29 cases of diuretics combined use, the effective rate was 79%. After treatment, the heart function improved from 3.3 before treatment to 2.3. Hemodynamic data show that after treatment, mean arterial pressure, right atrial pressure, pulmonary arterial pressure, peripheral and pulmonary vascular resistance decreased significantly; cardiac output and cardiac work index increased. Most patients are well tolerated. Discussing its function and mechanism.