目的:研究离子型和非离子型造影剂毒副反应发生率极其影响因素,建立临床使用离子型和非离子型造影剂的可行性方案;资料和方法:分析比较21508例CT增强检查患者资料,采用u检验法,对离子型和非离子型造影剂的毒副反应发生率,性别、预防措施以及高危人群对毒副反应发生率的影响进行统计学处理;结果:非离子型造影剂和离子型造影剂毒副反应总发生率分别为3.59％,10.24％,P<0.01。性别、不同的预防措施和高危人群的毒副作用的发生率均有显著性差异;结论:非离子型造影剂明显优于离子型造影剂。 Objective: To study the extremely influencing factors of the incidence of toxic and non-ionic contrast agents and establish the feasibility of clinical use of ionic and non-ionic contrast agents; Materials and Methods: 21,508 cases of enhanced CT examination data, The u test was used to analyze the incidence of toxic and side effects, sex, preventive measures and the incidence of toxic and side effects in high-risk groups. Results: The non-ionic contrast medium and ion Type of contrast agent the total incidence of toxic reactions were 3.59%, 10.24%, P <0.01. Gender, different preventive measures and the incidence of toxic and side effects in high-risk groups were significant differences; Conclusion: nonionic contrast agent was significantly better than the ionic contrast agent.