目的:建立紫外分光光度法测定吡菲尼酮片的溶出度。方法:采用中国药典附录XC第二法,以900 ml水为溶出介质,转速50 r·min~(-1),经30 min取样,在311nm.波长处检测。结果:吡菲尼酮在7.56～22.68μg·ml~(-1)的浓度范围内线性关系良好(r=0.999 7,n=5),平均回收率98.43%(n=6),主药溶出90%以上。结论:方法简便、准确,可有效检测其质量。 Objective: To establish a UV spectrophotometric method for the determination of dissolution of pirfenidone tablets. Methods: The Chinese Pharmacopoeia Appendix XC second method, with 900 ml of water as dissolution medium, speed 50 r · min -1, 30 min sampling, at 311 nm wavelength detection. Results: The calibration curve was linear over the concentration range of 7.56 ~ 22.68μg · ml -1 (r = 0.999 7, n = 5) and the average recovery was 98.43% (n = 6) More than 90. Conclusion: The method is simple, accurate and effective.