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氯氮平系二苯并二氮杂类衍生物,具有较强的抗精神病作用,临床引起癫病大发作少见报道,笔者遇及1例,现报告如下。患者,男,24岁,素健,无癫痫发作史,诊断为精神分裂症(青春型),于1986年12月20日首次住院,患者经氯丙嗪600mg/日加氟哌啶醇16mg/日治疗1月后精神症状明显好转出院。出院后患者未坚持服药,精神症状再次发生,于1987年3月17日入院。入院后予氯氮平治疗,初量50mg/日逐渐加至150mg/日,于加药的次日17点30分,患者昏迷跌倒于地,四肢强直,伴有尿失禁,口吐白沫,呼之不应,推之不动,头向右侧歪斜。
Clozapine dibenzodiazepines derivatives, has a strong anti-psychotic effect, clinical epilepsy seizures rarely reported, I encountered in 1 case, are as follows. Patients, male, 24 years old, Su Kin, history of seizures, diagnosed as schizophrenia (youth type), on December 20, 1986 first hospitalization, patients with chlorpromazine 600mg / day plus haloperidol 16mg / After January treatment, psychiatric symptoms improved significantly. Discharged patients did not adhere to medication, mental symptoms occur again, in March 17, 1987 admission. After admission to clozapine treatment, the initial amount of 50mg / day gradually increased to 150mg / day, at 17:30 on the next day of dosing, the patient coma fell to the ground, limbs stiff, accompanied by urinary incontinence, foaming at the mouth, Should not call, push motionless, head skewed to the right.