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目的观察消郁安神胶囊对慢性应激抑郁模型大鼠海马神经元形态的影响。方法对抑郁模型大鼠灌胃消郁安神胶囊,然后观察大鼠的空间学习记忆行为和海马神经元形态。结果慢性应激抑郁模型大鼠空间学习记忆能力明显下降,还能使海马CA1区和CA3区锥体细胞层变薄,细胞排列紊乱、疏松,胞浆尼氏体减少,并且出现大量神经元缺失,药物组动物改善明显。结论消郁安神胶囊能抵抗抑郁模型大鼠海马神经元的形态改变。
Objective To observe the effect of Xiao Yu Anshen Capsule on the morphology of hippocampal neurons in chronic stress depression model rats. Methods Depression model rats were fed with Xiaoyan Anshen Capsule, and then the spatial learning and memory behavior and hippocampal neuron morphology of the rats were observed. Results Chronic stress depression model rats spatial learning and memory ability decreased significantly, but also the hippocampal CA1 and CA3 pyramidal cell layer thinning, disordered cells, loose, reduced plasma Nissl, and a large number of neuronal loss The drug group improved significantly. Conclusion Xiao Yu Anshen Capsule can resist the morphological changes of hippocampal neurons in depression model rats.