目的动态观察根除Ｈｐ前后外周血Ｔ淋巴细胞亚群与组织学急性炎症反应，以及与血清促胃液素（Ｇａｓ），血浆、胃液生长抑素（ＳＳ）含量之间的相关变化．方法Ｈｐ＋十二指肠溃疡（ＤＵ）男性患者３２例，年龄２３岁～５１岁．对照组２２例均为Ｈｐ－浅表性胃炎（ＣＳＧ）男性患者，年龄２２岁～４９岁．两组患者均于空腹下作内镜，留取胃液，并在胃窦取组织，常规作尿素酶试验和组织学检查．同时取静脉血，采用ＡＰＡＡＰ方法和放射免疫法检测外周血Ｔ淋巴细胞亚群及血清Ｇａｓ，血浆ＳＳ含量．ＤＵ组患者接受抗Ｈｐ三联治疗，并于治疗后６０ｄ分别重复上述检查．结果３２例中，失访８例，余２４例Ｈｐ根除２０例（８３３％），未根除４例（１６７％）．抗菌治疗前，３２例ＤＵ患者Ｔ淋巴细胞亚群ＣＤ３（％），ＣＤ４（％）及ＣＤ４／ＣＤ８比值（３７０±１２，１９９±１０，１０±０１）显著低于对照组（５０５±１５，Ｐ＜００１；２７０±１３，Ｐ＜００５；１７±０１，Ｐ＜００１）；ＣＤ８（％）虽较对照组增高（２５５±２１ｖｓ１７７±１１），但无统计学意义．２０例Ｈｐ根除者中，ＣＤ３（％），ＣＤ４（％）及ＣＤ４／ＣＤ８比值上升的患者? Objective To observe the changes of peripheral blood T lymphocyte subsets and histological acute inflammatory response before and after eradication of Hp, and to investigate the relationship between the levels of serum gastrin, plasma and gastric somatostatin (SS). Methods Hp + duodenal ulcer (DU) in 32 male patients, aged 23 to 51 years. The control group of 22 patients were Hp-superficial gastritis (CSG) male patients, aged 22 to 49 years. Both groups were under endoscopy in fasting, gastric juice was taken, and the tissue taken in the antrum, routine urease test and histological examination. At the same time take venous blood, using APAAP method and radioimmunoassay to detect peripheral blood T lymphocyte subsets and serum Gas, plasma SS content. Patients in DU group were treated with anti-Hp triple therapy and were repeated 60 days after treatment. Results Among the 32 cases, 8 were lost to follow-up, and the remaining 24 patients were eradication in 20 cases (833%) and 4 cases (167%) without eradication. Before antimicrobial therapy, 32 cases of DU patients T lymphocyte subsets CD3 (%), CD4 (%) and CD4 / CD8 ratio (37  1  1  2, 19  9 ± 1  0,1  0  0  1) was significantly lower than that of the control group (505 ± 15, P <001; 270 ± 13, P <005; 17 ± 01, P <001) ; CD8 (%) was higher than the control group (255 ± 21vs177 ± 11), but no statistical significance. 20 patients with Hp eradication, CD3 (%), CD4 (%) and CD4 / CD8 ratio of patients?